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Modification of ginsenoside saponin composition via the CRISPR/Cas9-mediated knockout of protopanaxadiol 6-hydroxylase gene in Panax ginseng

They address the root cause follicle miniaturisation and dermal papilla cell death rather than just masking symptoms

However, a potential drawback is that KD is typically low in dietary Trp [178], the precursor of several neuroprotective AhR ligands and serotonin pathway metabolites